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What Is VDR?

https://www.gescheftmarketing.de/2022/03/14/virtual-data-rooms-as-a-part-of-secure-business-practices/

VDR is a gene which codes for a vitamin D receptor protein. This protein regulates calcium absorption as well as bone development. A variant of the gene, rs2228570 (FokI polymorphism) is associated with a decrease in bone mineral density in white prepubertal girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by the two components, and it is influenced by chromosomal locations and by binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes carry a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository for information and documents relevant to legal, business, or proceedings that are restricted in viewing, downloading or printing. It is accessed via central computers and an extranet which is a restricted access Internet connection, to allow users to login at specified times.

VDRs are used most often by investment banks and businesses involved in mergers or acquisitions. They require a secure platform for sharing information with potential buyers or investors in a way that is transparent and due diligence could require huge amounts of information. Life science companies also utilize VDRs for everything from clinical trial data to HIPAA compliance documentation.

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